Pontisso P, Ruvoletto M G, Fattovich G, Chemello L, Gallorini A, Ruol A, Alberti A
Istituto di Medicina Clinica, Università di Padova, Italy.
Gastroenterology. 1993 Nov;105(5):1529-33. doi: 10.1016/0016-5085(93)90161-5.
The "in vivo" interplay between hepatitis B virus (HBV) and hepatitis C virus (HCV) both in terms of replication activity and cytopathic effect on liver cells is poorly understood. The aim of the study was to investigate their reciprocal influence in patients with HBV and HCV coinfection.
HBV and HCV genomic sequences in the serum and liver of 55 patients with chronic liver disease who were positive for anti-HCV and for markers of HBV were studied.
Twenty-five hepatitis B surface antigen-positive patients, without markers of hepatitis D virus (HDV) infection, showed an inverse relation between seropositivity for HCV RNA and for HBV DNA (P < 0.001). HCV genomic sequences were detected in the liver of all patients positive for HBV DNA but negative for HCV RNA in serum. The biochemical activity and the histological severity of liver disease were lower in HCV RNA-positive/HBV DNA-negative patients, compared with HCV RNA (serum)-negative/HBV DNA-positive cases (P < 0.005). Nine of 10 patients with concurrent HDV infection were negative for serum and liver HCV RNA. None of 20 hepatitis B surface antigen-negative/HCV RNA-positive patients with antibodies to HBV had HBV DNA detectable in serum or liver.
Our findings indicate a reciprocal inverse relation between HBV and HCV replication. Patients positive for antibody to HCV with antibodies to HBV usually have no evidence of HBV DNA persistence in the liver.
乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）在复制活性以及对肝细胞的细胞病变效应方面的“体内”相互作用尚不清楚。本研究的目的是调查HBV和HCV合并感染患者中它们的相互影响。
研究了55例慢性肝病患者血清和肝脏中的HBV和HCV基因组序列，这些患者抗HCV和HBV标志物均呈阳性。
25例乙型肝炎表面抗原阳性且无丁型肝炎病毒（HDV）感染标志物的患者，HCV RNA血清阳性与HBV DNA血清阳性呈负相关（P < 0.001）。在所有HBV DNA阳性但血清HCV RNA阴性的患者肝脏中均检测到HCV基因组序列。与HCV RNA（血清）阴性/HBV DNA阳性病例相比，HCV RNA阳性/HBV DNA阴性患者的肝病生化活性和组织学严重程度较低（P < 0.005）。10例合并HDV感染的患者中有9例血清和肝脏HCV RNA呈阴性。20例乙型肝炎表面抗原阴性/HCV RNA阳性且有HBV抗体的患者中，血清或肝脏中均未检测到HBV DNA。
我们的研究结果表明HBV和HCV复制之间存在相互负相关关系。抗HCV抗体和抗HBV抗体均阳性的患者肝脏中通常没有HBV DNA持续存在的证据。
