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蓝氏贾第鞭毛虫生命周期完成后，滋养体可变表面蛋白TSA 417的抗原转换。

Antigenic switching of TSA 417, a trophozoite variable surface protein, following completion of the life cycle of Giardia lamblia.

作者信息

Meng T C, Hetsko M L, Gillin F D

机构信息

Department of Medicine, University of California, San Diego Medical Center 92103-8416.

出版信息

Infect Immun. 1993 Dec;61(12):5394-7. doi: 10.1128/iai.61.12.5394-5397.1993.

DOI:10.1128/iai.61.12.5394-5397.1993
PMID:8225614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC281329/
Abstract

Expression of TSA 417, the predominant cysteine-rich variable surface protein of Giardia lamblia WB clone C6 trophozoites, did not change during encystation in vitro. However, in vitro excystation of cysts derived in vitro or in vivo consistently produced TSA 417 nonexpressing trophozoite populations, suggesting that completion of the life cycle leads to antigenic switching.

摘要

贾第虫WB克隆C6滋养体中主要的富含半胱氨酸的可变表面蛋白TSA 417在体外包囊化过程中表达没有变化。然而，体外或体内来源的包囊进行体外脱囊时始终产生不表达TSA 417的滋养体群体，这表明生命周期的完成会导致抗原转换。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eecf/281329/4e91d843a3be/iai00024-0465-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eecf/281329/4e91d843a3be/iai00024-0465-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eecf/281329/4e91d843a3be/iai00024-0465-a.jpg

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Improved in vitro excystation procedure for Giardia lamblia cysts.改进的蓝氏贾第鞭毛虫囊肿体外脱囊程序。
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Experimental infections of neonatal mice with cysts of Giardia lamblia clone GS/M-83-H7 are associated with an antigenic reset of the parasite.用蓝氏贾第鞭毛虫克隆株GS/M-83-H7的包囊对新生小鼠进行实验性感染，与该寄生虫的抗原重置有关。
Infect Immun. 2004 Aug;72(8):4763-71. doi: 10.1128/IAI.72.8.4763-4771.2004.
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Simultaneous expression of different variant-specific surface proteins in single Giardia lamblia trophozoites during encystation.在包囊形成过程中，单个蓝氏贾第鞭毛虫滋养体中不同变体特异性表面蛋白的同时表达。
Infect Immun. 2002 Sep;70(9):5265-8. doi: 10.1128/IAI.70.9.5265-5268.2002.
7
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8
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Clin Microbiol Rev. 2001 Jul;14(3):447-75. doi: 10.1128/CMR.14.3.447-475.2001.
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