与罗红霉素和克拉霉素相比，交沙霉素对耐红霉素葡萄球菌的抗菌活性。

Antimicrobial activity of josamycin against erythromycin-resistant staphylococci as compared to roxythromycin and clarithromycin.

作者信息

Guggenbichler J P, Georgopoulos A, Scharrer P, Kobilansky C, Mühlbacher J, Georgopoulos M, Dierich M P

机构信息

Universitätsklinik für Kinder und Jugendliche, Erlangen, Germany.

出版信息

Infection. 1993 Jul-Aug;21(4):259-61. doi: 10.1007/BF01728908.

DOI:10.1007/BF01728908

PMID:8225634

Abstract

In an in vitro study 246 clinical isolates of erythromycin-resistant staphylococci from six hospitals in Austria were investigated for susceptibility to josamycin and other, newer macrolide antibiotics, e.g. roxithromycin and clarithromycin. 71 strains of Staphylococcus aureus showed an MIC > or = 4 mg/l and 100 strains of S. aureus showed an MIC > or = 256 mg/l. In addition, 25 strains of coagulase-negative staphylococci resistant to erythromycin at an MIC of > or = 4 mg/l were investigated. At an MIC of 2 mg/l 57% of the erythromycin-resistant strains of S. aureus were inhibited by josamycin, 25% by clarithromycin and 11.6% by roxithromycin. At an MIC of 2 mg/l 13.3% of erythromycin-resistant coagulase-negative staphylococci were inhibited by josamycin, 10.7% by clarithromycin and 9.3% by roxithromycin. This study suggests that josamycin is still active in vitro against more than 50% of erythromycin-resistant strains of S. aureus. This drug is also more active than roxithromycin and clarithromycin against erythromycin-resistant S. aureus.

摘要

在一项体外研究中，对来自奥地利六家医院的246株耐红霉素葡萄球菌临床分离株进行了对交沙霉素及其他新型大环内酯类抗生素（如罗红霉素和克拉霉素）的敏感性研究。71株金黄色葡萄球菌的最低抑菌浓度（MIC）≥4mg/L，100株金黄色葡萄球菌的MIC≥256mg/L。此外，还对25株凝固酶阴性葡萄球菌进行了研究，这些菌株对红霉素耐药，MIC≥4mg/L。在MIC为2mg/L时，57%的耐红霉素金黄色葡萄球菌菌株被交沙霉素抑制，25%被克拉霉素抑制，11.6%被罗红霉素抑制。在MIC为2mg/L时，13.3%的耐红霉素凝固酶阴性葡萄球菌被交沙霉素抑制，10.7%被克拉霉素抑制，9.3%被罗红霉素抑制。这项研究表明，交沙霉素在体外对超过50%的耐红霉素金黄色葡萄球菌菌株仍有活性。该药物对耐红霉素金黄色葡萄球菌的活性也高于罗红霉素和克拉霉素。