7,12-二甲基苯并蒽诱导的大鼠乳腺肿瘤对孕酮和美法仑的体外反应异质性
Heterogeneity in in vitro response to progesterone and melphalan of mammary tumours induced in the rat by 7,12-DMBA.
作者信息
Aspegren K, Biörklund A, Tropé C
出版信息
Acta Pathol Microbiol Scand A. 1976 Jul;84(4):297-300. doi: 10.1111/j.1699-0463.1976.tb00117.x.
Abstract
Five mammary tumours induced in rats by 7, 12-DMBA were each divided into four sections, and studied as cell suspensions in vitro for response to melphalan or progesterone measured as H3-thymidine incorporation. Heterogeneity towards melphalan and progesterone was found within all five tumours, but the mode of reaction of the two drugs differed. The biological relevance of these findings is discussed.
摘要
用7,12 - 二甲基苯并蒽诱导大鼠产生的5个乳腺肿瘤，每个肿瘤均被分成4部分，并作为体外细胞悬液进行研究，以3H - 胸腺嘧啶核苷掺入量来测定对美法仑或孕酮的反应。在所有5个肿瘤中均发现了对美法仑和孕酮的异质性，但两种药物的反应模式不同。讨论了这些发现的生物学意义。
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