Beck F W, Whitehouse M W
Agents Actions. 1976 Jul;6(4):460-7. doi: 10.1007/BF01973260.
EAE induced in Lewis rats by guinea-pig spinal cord and such lipid adjuvants as hexadecane or squalene (without the mycobacterial component) is more sensitive to lower doses of cyclophosphamide and some select immunosuppressive agents than the conventional EAE induced using Freund's complete adjuvant. In addition, these animals do not suffer from adjuvant arthritis which may be induced if the bacterial component is present. These modifications in the conventional assay have enhanced its ability to detect new, weaker and/or lower doses of known immunosuppressants.
用豚鼠脊髓以及十六烷或角鲨烯等脂质佐剂（不含分枝杆菌成分）在Lewis大鼠中诱导的实验性自身免疫性脑脊髓炎（EAE），比使用弗氏完全佐剂诱导的传统EAE对更低剂量的环磷酰胺和某些选定的免疫抑制剂更敏感。此外，这些动物不会患上如果存在细菌成分可能诱导的佐剂性关节炎。传统检测方法中的这些改进增强了其检测新的、较弱和/或较低剂量已知免疫抑制剂的能力。
