对中枢神经系统感染性疾病的免疫反应：一种脆弱的平衡。
The immune response to infectious diseases of the central nervous system: a tenuous balance.
作者信息
Pachner A R
机构信息
Department of Neurology, Georgetown University Medical Center, Washington DC 20007-2197, USA.
出版信息
Springer Semin Immunopathol. 1996;18(1):25-34. doi: 10.1007/BF00792606.
The outcome of CNS infection is dependent on both the organism and host. Acute infections are usually cleared with minimal residua. However, chronic infections of the CNS, such as HIV, PML, HSV, polio, Lyme neuroborreliosis, and neurosyphilis, are becoming increasingly recognized as a cause of severe neurological morbidity, and are poorly understood. We will need to learn more about the CNS as an immune compartment to increase our knowledge of these infections.
中枢神经系统感染的结果取决于病原体和宿主双方。急性感染通常能被清除，残留极少。然而，中枢神经系统的慢性感染，如艾滋病病毒、进行性多灶性白质脑病、单纯疱疹病毒、脊髓灰质炎、莱姆神经疏螺旋体病和神经梅毒，正日益被视为严重神经功能障碍的一个病因，且人们对此了解甚少。我们需要更多地了解作为一个免疫区室的中枢神经系统，以增进我们对这些感染的认识。
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