Yokoyama H, Shibata T, Kubota N, Matsuo R, Takahashi K
Department of Anesthesia, Tohyoko General Hospital, St. Marianna University School of Medicine, Kawasaki.
Masui. 1993 Oct;42(10):1418-22.
We examined the effects of sevoflurane anesthesia with hypothermia on ischemic brain cellular respiration using Wistar strain rats. Ischemia was induced by decapitation. L/P in brain increased during no anesthesia-normothermia-ischemia (1), then gradually, but not fully recovered during 2.5% sevoflurane anesthesia-normothermia-ischemia (2) and during 2.5% sevoflurane anesthesia-hypothermia-ischemia (3). Energy charge decreased during (1) and slight recovery was observed during (3). Respiratory control ratio in brain mitochondria decreased during (1) and recovery during (2) and (3) was slight. No recovery was observed in ADP/O. These findings indicate that during sevoflurane anesthesia with hypothermia, ischemic brain energy metabolism has an effect not on the mitochondrial energy producing processes but on the consuming system.
我们使用Wistar品系大鼠研究了七氟醚麻醉联合低温对缺血性脑细 胞呼吸的影响。通过断头诱导缺血。在无麻醉-正常体温-缺血（1）期间，脑内的L/P升高，然后在2.5%七氟醚麻醉-正常体温-缺血（2）以及2.5%七氟醚麻醉-低温-缺血（3）期间逐渐升高，但未完全恢复。在（1）期间能量电荷降低，在（3）期间观察到轻微恢复。脑线粒体中的呼吸控制率在（1）期间降低，在（2）和（3）期间仅有轻微恢复。ADP/O未观察到恢复。这些发现表明，在七氟醚麻醉联合低温期间，缺血性脑能量代谢对线粒体能量产生过程没有影响，而是对消耗系统有影响。
