Doi M, Ikeda K
Anesth Analg. 1987 Mar;66(3):241-4.
The respiratory effects of sevoflurane were studied in seven patients and compared with values obtained in another seven patients anesthetized with halothane. Resting ventilation, resting PaCO2, and ventilatory response to CO2 were measured awake and at 1.1 and 1.4 MAC levels of both anesthetic agents. We found that with sevoflurane, tidal volume and the slopes of the CO2 response curves decreased and PaCO2 increased with increasing depth of anesthesia, as with other inhaled anesthetics. A compensatory increase in respiratory frequency was not enough to prevent a decrease in minute volume with increasing depth of anesthesia. At 1.1 MAC, sevoflurane produced almost the same degree of respiratory depression as halothane. At 1.4 MAC, sevoflurane produced more profound respiratory depression than halothane.
对7例患者研究了七氟烷的呼吸效应，并与另外7例接受氟烷麻醉的患者所获数值进行比较。在两种麻醉剂的清醒状态、1.1和1.4MAC水平下测量静息通气、静息PaCO2以及对CO2的通气反应。我们发现，与其他吸入麻醉剂一样，使用七氟烷时，随着麻醉深度增加，潮气量和CO2反应曲线斜率降低，PaCO2升高。随着麻醉深度增加，呼吸频率的代偿性增加不足以防止分钟通气量下降。在1.1MAC时，七氟烷产生的呼吸抑制程度与氟烷几乎相同。在1.4MAC时，七氟烷产生的呼吸抑制比氟烷更严重。
