Ueno Y, Saito R, Hata T
Department of Life Chemistry, Tokyo Institute of Technology, Yokohama, Japan.
Nucleic Acids Res. 1993 Sep 25;21(19):4451-7. doi: 10.1093/nar/21.19.4451.
The preparation of a nucleotidyl-peptide having a thymidine-5'-yl-(P-O)-serine phosphodiester bond, H-Ala-Ser(pTpT)-Phe-OH is described. After condensation between the phosphorylated peptide component and an oligonucleotide component, all protecting groups could be removed under neutral conditions without beta-elimination of the pTpT from the serine moiety.