H-Phe-Tyr-(pATAT)-NH2的固相合成：来自噬菌体phi X174核蛋白的一个核肽片段。
Solid-phase synthesis of H-Phe-Tyr-(pATAT)-NH2: a nucleopeptide fragment from the nucleoprotein of bacteriophage phi X174.
作者信息
Dreef-Tromp C M, van Dam E M, van den Elst H, van der Marel G A, van Boom J H
机构信息
Gorlaeus Laboratories, Leiden, The Netherlands.
出版信息
Nucleic Acids Res. 1990 Nov 25;18(22):6491-5. doi: 10.1093/nar/18.22.6491.
Abstract
The preparation of the nucleopeptide H-Phe-Tyr-(pATAT)-NH2 could be realized via a solid phase phosphitetriester approach and by using the protected protecting group 2-(tert-butyldiphenylsilyoxymethyl)-benzoyl for the masking of the N6-amino function of deoxyadenosine. The latter protecting group can be removed under mild conditions with fluoride ion.
摘要
核肽H-Phe-Tyr-(pATAT)-NH2的制备可通过固相亚磷酸三酯法实现，并使用保护基团2-(叔丁基二苯基硅氧基甲基)-苯甲酰基来掩蔽脱氧腺苷的N6-氨基功能。后一种保护基团可在温和条件下用氟离子除去。
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