通过磷酸三酯法合成核肽H-Phe-Tyr(pGC)-NH2和H-Phe-Ser(pGC)-Ala-OH。
Synthesis of the nucleopeptides H-Phe-Tyr(pGC)-NH2 and H-Phe-Ser(pGC)-Ala-OH via a phosphotriester approach.
作者信息
Kuyl-Yeheskiely E, Dreef-Tromp C M, Geluk A, van der Marel G A, van Boom J H
机构信息
Gorlaeus Laboratories, Leiden University, The Netherlands.
出版信息
Nucleic Acids Res. 1989 Apr 25;17(8):2897-905. doi: 10.1093/nar/17.8.2897.
Abstract
Use of the protecting groups di-n-butylaminomethylene,2-nitrophenylsulfenyl and the ester of 2-(hydroxymethyl)-9,10-anthraquinone, enabled us for the first time to prepare nucleopeptide fragments containing 2'-deoxyguanosine and a free carboxylic acid group.
摘要
使用保护基团二正丁基氨基亚甲基、2-硝基苯硫基以及2-(羟甲基)-9,10-蒽醌的酯，使我们首次能够制备含有2'-脱氧鸟苷和游离羧酸基团的核苷肽片段。
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Synthesis of the nucleopeptides H-Phe-Tyr(pGC)-NH2 and H-Phe-Ser(pGC)-Ala-OH via a phosphotriester approach.通过磷酸三酯法合成核肽H-Phe-Tyr(pGC)-NH2和H-Phe-Ser(pGC)-Ala-OH。
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本文引用的文献
1
Protein p3 is linked to the DNA of phage phi 29 through a phosphoester bond between serine and 5'-dAMP.蛋白质p3通过丝氨酸与5'-二磷酸腺苷之间的磷酸酯键与噬菌体φ29的DNA相连。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6425-8. doi: 10.1073/pnas.77.11.6425.
2
Dialkylformamidines: depurination resistant N6-protecting group for deoxyadenosine.二烷基甲脒：用于脱氧腺苷的抗脱嘌呤N6保护基团。
Nucleic Acids Res. 1983 Nov 25;11(22):8031-6. doi: 10.1093/nar/11.22.8031.
3
The bond in the bacteriophage phi X174 gene A protein--DNA complex is a tyrosyl-5'-phosphate ester.噬菌体φX174基因A蛋白与DNA复合物中的键是酪氨酰-5'-磷酸酯。
FEBS Lett. 1984 Aug 6;173(2):351-6. doi: 10.1016/0014-5793(84)80804-2.
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The 2-nitrophenylsulfenyl (Nps) group for the protection of amino functions of cytidine, adenosine, guanosine and their 2'-deoxysugar derivatives.用于保护胞苷、腺苷、鸟苷及其2'-脱氧糖衍生物氨基功能的2-硝基苯硫基（Nps）基团。
Acta Chem Scand B. 1983;37(9):857-62. doi: 10.3891/acta.chem.scand.37b-0857.
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A model study directed towards the preparation of nucleopeptides via H-phosphonate intermediates.一项旨在通过H-膦酸酯中间体制备核肽的模型研究。
Nucleic Acids Res. 1987 Feb 25;15(4):1807-18. doi: 10.1093/nar/15.4.1807.
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