Pollak P, Benabid A L, Gross C, Gao D M, Laurent A, Benazzouz A, Hoffmann D, Gentil M, Perret J
Département des Neurosciences Cliniques et Biologiques, Centre Hospitalier Universitaire de Grenoble, France.
Rev Neurol (Paris). 1993;149(3):175-6.
In Parkinson's disease, experimental studies favour a neuronal hyperactivity of the subthalamic nucleus. We carried out a subthalamic nucleus electrical stimulation in a patient aged 51, suffering for 8 years from a severe akineto-rigid form of Parkinson's disease, complicated with an on-off effect. Stereotaxic surgery was done under local anaesthesia on one side. Within the theoretical target, a 130 Hz stimulation induced akinesia alleviation mainly on the contralateral limbs. No abnormal movement was noticed. Then a long-term quadripolar DBS Medtronic electrode was inserted in that area. The study of the effects of chronic stimulation is in progress to determine the best temporal and electrical stimulation variables.
在帕金森病中，实验研究倾向于认为底丘脑核存在神经元活动亢进。我们对一名51岁的患者进行了底丘脑核电刺激，该患者患有严重的运动不能 - 强直型帕金森病8年，伴有开关现象。在局部麻醉下对一侧进行了立体定向手术。在理论靶点内，130赫兹的刺激主要使对侧肢体的运动不能得到缓解。未观察到异常运动。然后在该区域插入了一根美敦力长期四极深部脑刺激电极。慢性刺激效果的研究正在进行中，以确定最佳的时间和电刺激参数。
