Castellano C
Psychopharmacology (Berl). 1976 Jul 9;48(1):37-43. doi: 10.1007/BF00423304.
DBA/2J and C57BL/6J mice were injected with nicotine, and tested in a Y water maze in two procedures: the L procedure, coresponding to innate behavior, in which the animals must swim towards the light, and the D procedure, corresponding to the acquisition of a new pattern of behavior, in which they must swim toward the dark. Three sets of experiments were carried out: 1. In the pre-trial experiments, nicotine administration improved the innate tendencies of both strains, while the acquisition of a new behavior was facilitated in the C57 and impaired in the DBA mice. 2. In the post-trial experiments (D procedure), nicotine administration induced clear facilitating effects on the consolidation processes of the C57, while impairing these processes in the DBA strain. 3. The only effect evident, following nicotine administration, before the highest doses were reached, in the trained mice of both strains, was a performance impairment of the DBA mice trained in the L procedure.
将DBA/2J和C57BL/6J小鼠注射尼古丁，并在Y型水迷宫中通过两种程序进行测试：L程序，对应于先天行为，即动物必须游向光亮处；D程序，对应于新行为模式的习得，即它们必须游向黑暗处。进行了三组实验：1. 在预试验实验中，给予尼古丁改善了两个品系的先天倾向，而C57小鼠新行为的习得得到促进，DBA小鼠则受到损害。2. 在试验后实验（D程序）中，给予尼古丁对C57小鼠的巩固过程有明显的促进作用，而对DBA品系则损害这些过程。3. 在达到最高剂量之前，对两个品系的训练小鼠给予尼古丁后，唯一明显的效应是在L程序中训练的DBA小鼠的表现受损。
