Jespersen A
Acta Pathol Microbiol Scand B. 1976 Oct;84B(5):265-72. doi: 10.1111/j.1699-0463.1976.tb01936.x.
Infection experiments have shown that red mice, belonging to the vole family, could be infected with Listeria monocytogenes and that they were almost as susceptible to intravenous infection as Cf1 mice. Vaccination of red mice with BCG induced a resistance which could be demonstrated by prologation of the survival time of the animals after challenge with Listeria. The resistance was greatest in the second and third week after vaccination and was considerably higher after intravenous injection of BCG vaccine than after intraperitoneal or subcutaneous injection. On the basis of studies concerning the dose of vaccine, the route of vaccination, and the interval between vaccination and challenge, a method by which to evaluate the potency of a strain of BCG has been elaborated. By this method it was found that there was a significant difference between the resistance produced by a strain of BCG which is weakly virulent and one which is strongly virulent for hamsters.
感染实验表明，属于田鼠科的红小鼠可被单核细胞增生李斯特菌感染，并且它们对静脉注射感染的易感性几乎与Cf1小鼠相同。用卡介苗对红小鼠进行疫苗接种可诱导产生抵抗力，这可通过在感染李斯特菌后延长动物的存活时间来证明。接种疫苗后第二周和第三周抵抗力最强，静脉注射卡介苗疫苗后的抵抗力明显高于腹腔或皮下注射后的抵抗力。基于有关疫苗剂量、接种途径以及接种与感染之间间隔的研究，已制定出一种评估卡介苗菌株效力的方法。通过这种方法发现，对仓鼠弱毒的卡介苗菌株产生的抵抗力与强毒的卡介苗菌株产生的抵抗力之间存在显著差异。
