Aaby P, Samb B, Simondon F, Knudsen K, Seck A M, Bennett J, Whittle H
ORSTOM, Dakar, Senegal.
Am J Epidemiol. 1993 Nov 1;138(9):746-55. doi: 10.1093/oxfordjournals.aje.a116912.
The female/male mortality ratio among unimmunized children and children vaccinated with standard or high-titer measles vaccines was examined for all children born in the period 1985-1991 in a rural area of Senegal. The female/male mortality ratio from 9 months to 5 years of age for unvaccinated children was 0.94 (95% confidence interval (CI) 0.75-1.19), significantly different from the ratio of 0.64 (95% CI 0.48-0.85) for recipients of the Schwarz standard measles vaccine (p = 0.040). In the 4-year period, where high-titer measles vaccines were used in the study area, the female/male mortality ratio was 1.33 (95% CI 1.00-1.78) for recipients of high-titer Edmonston-Zagreb or Schwarz vaccines compared with 0.67 (95% CI 0.42-1.07) for recipients of the Schwarz standard vaccine (p = 0.013). Hence, the Schwarz standard and high-titer measles vaccines have divergent sex-specific effects on mortality throughout childhood. Further studies of the underlying mechanisms are needed.
对塞内加尔农村地区1985年至1991年期间出生的所有儿童，研究了未接种疫苗儿童以及接种标准或高滴度麻疹疫苗儿童的女性/男性死亡率。未接种疫苗儿童9个月至5岁的女性/男性死亡率为0.94（95%置信区间（CI）0.75 - 1.19），与接种施瓦茨标准麻疹疫苗儿童的0.64（95% CI 0.48 - 0.85）有显著差异（p = 0.040）。在研究地区使用高滴度麻疹疫苗的4年期间，接种高滴度埃德蒙斯顿- Zagreb或施瓦茨疫苗儿童的女性/男性死亡率为1.33（95% CI 1.00 - 1.78），而接种施瓦茨标准疫苗儿童的为0.67（95% CI 0.42 - 1.07）（p = 0.013）。因此，施瓦茨标准和高滴度麻疹疫苗在儿童期对死亡率有不同的性别特异性影响。需要对潜在机制进行进一步研究。
