吸入性BRL 10833对变应原诱导的支气管痉挛的保护作用。
The protective effect of inhaled BRL 10833 on allergen induced bronchospasm.
作者信息
Pauwels R, Lamont H, Van der Straeten M
出版信息
Clin Allergy. 1976 Sep;6(5):463-9. doi: 10.1111/j.1365-2222.1976.tb01930.x.
BRL 10833, a nitroindanedione, with similar inhibitory activities to DSCG on the immediate type IgE mediated hypersensitivity in the rat, has been shown, when inhaled in a dose of 40 mg, to protect against allergen induced bronchospasm. A significant protective effect of BRL 10833 on the immediate bronchial reaction was seen in five out of ten patients. A single inhalation of 40 mg BRL 10833 seems also to have some protective effect on the late bronchial reaction, following an immediate reaction.
BRL 10833是一种硝基茚二酮，对大鼠IgE介导的速发型超敏反应具有与色甘酸钠（DSCG）相似的抑制活性。当以40毫克的剂量吸入时，它已被证明能预防变应原诱导的支气管痉挛。在十名患者中有五名患者观察到BRL 10833对速发性支气管反应有显著的保护作用。单次吸入40毫克BRL 10833似乎对速发反应后的迟发性支气管反应也有一定的保护作用。
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