Pauwels R, Lamont H, Van der Straeten M
Clin Allergy. 1976 Sep;6(5):471-8. doi: 10.1111/j.1365-2222.1976.tb01931.x.
BRL 10833, a nitroindanedione, with DSCG like activity in rat immediate type hypersensitivity, shows good absorption after oral intake in man. The ingestion of 2 and 10 mg BRL 10833/kg body weight provides protection against the immediate type allergen induced bronchoconstriction in patients with bronchial asthma. These results confirm the activity of the drug shown by inhalation.
BRL 10833是一种硝基茚二酮，在大鼠速发型超敏反应中具有类似色甘酸钠（DSCG）的活性，人体口服后吸收良好。摄入2毫克和10毫克/千克体重的BRL 10833可预防支气管哮喘患者因速发型过敏原诱发的支气管收缩。这些结果证实了该药物经吸入给药所显示的活性。
