Grunwald G B
Department of Anatomy and Developmental Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Curr Opin Cell Biol. 1993 Oct;5(5):797-805. doi: 10.1016/0955-0674(93)90028-o.
During the past year considerable progress has been made in our understanding of cadherin structure and function. Recent research has concentrated on several aspects of the cell and molecular biology of cadherins, including genomic organization, cytoskeletal interactions, regulation of expression and function by post-translational modifications, differential expression during embryonic development, and the emerging role of cadherin misexpression and malfunction in pathogenesis.
在过去的一年里，我们对钙黏蛋白结构和功能的理解取得了显著进展。最近的研究集中在钙黏蛋白的细胞和分子生物学的几个方面，包括基因组组织、细胞骨架相互作用、翻译后修饰对表达和功能的调节、胚胎发育过程中的差异表达，以及钙黏蛋白表达异常和功能异常在发病机制中日益显现的作用。
