Xiang Z X, He X Q, Zhou G F, Li C H
Zhongguo Zhong Yao Za Zhi. 1989 May;14(5):303-5, 320.
The ethanolic extract and the essential oil of Curcuma kwangsinensis were found to be effective in lowering the elevated SGPT induced by CCl4, TAA and BSP retention. Histological examination showed that hepatic damages of the extract-and oil-pretreated mice were less than those of the CCl4 control group. The ethanolic extract helped to shorten sodium pentobarbital sleeping time in both normal and CCl4 intoxicated mice. In addition, the essential oil exhibited an inhibitory effect on triglyceride accumulation in mice. The toxicity of the extract and the oil was found to be low: oral LD50 was 86.8 +/- 12g crude drug/kg (ethanolic extract) and 1.10 +/- 0.08g/kg (essential oil).
研究发现，广西莪术的乙醇提取物和挥发油对四氯化碳、硫代乙酰胺和溴磺酚酞潴留诱导的血清谷丙转氨酶升高具有降低作用。组织学检查显示，提取物和挥发油预处理小鼠的肝损伤小于四氯化碳对照组。乙醇提取物有助于缩短正常小鼠和四氯化碳中毒小鼠的戊巴比妥钠睡眠时间。此外，挥发油对小鼠甘油三酯积累具有抑制作用。提取物和挥发油的毒性较低：口服半数致死量分别为86.8±12克生药/千克（乙醇提取物）和1.10±0.08克/千克（挥发油）。
