Woollen B H
Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, U.K.
Ann Occup Hyg. 1993 Oct;37(5):525-40. doi: 10.1093/annhyg/37.5.525.
This paper reviews the development of biological monitoring as a method of assessing absorption of pesticides during occupational exposure. An approach to human volunteer studies to estimate the relationship between exposure to pesticides and excretion of metabolites is described and practical aspects of applying biological monitoring to field studies are considered. Case studies are used to illustrate some of the pitfalls of extrapolating from animals to man and to demonstrate the importance of human volunteer studies in establishing a sound basis for biological monitoring for pesticides.
本文综述了生物监测作为评估职业接触农药时吸收情况的一种方法的发展。描述了一种用于人类志愿者研究以估计农药接触与代谢物排泄之间关系的方法，并考虑了将生物监测应用于现场研究的实际问题。通过案例研究来说明从动物推断到人类的一些陷阱，并证明人类志愿者研究在为农药生物监测建立坚实基础方面的重要性。
