Zerbib F, Vialette G, Cayla R, Rudelli A, Sauvet P, Bechade D, Seurat P L, Lamouliatte H
Service de Gastroentérologie, HIA Robert-Picqué, Bordeaux-Armées.
Gastroenterol Clin Biol. 1993;17(8-9):529-34.
Follicular gastritis (FG) is characterized by lymphoid follicle hyperplasia in the gastric mucosa. The aim of this prospective study was to determine the prevalence of FG in adults, their relation to Helicobacter pylori infection, and their histological and endoscopic features. Of 445 patients (379 men, 66 women), 36.4 years old (range: 18-86), FG was detected in 63 patients (14.2%). This was highly significantly associated with H. pylori infection: 49/138 infected patients (35.5%) versus 14/307 non infected patients (4.6%) (P < 0.001). None of the histological features of the antral mucosa were correlated with FG. The prevalence of FG in patients less than 20 years old (in 45.4%) and between 20 and 40 years (in 41.3%) was higher than in patients aged from 40 to 60 years (in 33%) and older than 60 years (in 23%) (no significant difference). No one endoscopic feature of the gastric mucosa was predictive of the presence of FG. We conclude that FG is highly correlated with H. pylori infection and represents a local immune response to bacterial antigens. Their occurrence is probably multifactorial and related to age, duration of infection, bacterial strains, host immune status.
滤泡性胃炎（FG）的特征是胃黏膜中淋巴滤泡增生。这项前瞻性研究的目的是确定成人FG的患病率、其与幽门螺杆菌感染的关系以及其组织学和内镜特征。在445例患者（379例男性，66例女性）中，年龄为36.4岁（范围：18 - 86岁），63例患者（14.2%）检测到FG。这与幽门螺杆菌感染高度显著相关：138例感染患者中有49例（35.5%），而307例未感染患者中有14例（4.6%）（P < 0.001）。胃窦黏膜的组织学特征均与FG无关。小于20岁患者（45.4%）和20至40岁患者（41.3%）中FG的患病率高于40至60岁患者（33%）和60岁以上患者（23%）（无显著差异）。胃黏膜的内镜特征均不能预测FG的存在。我们得出结论，FG与幽门螺杆菌感染高度相关，代表了对细菌抗原的局部免疫反应。其发生可能是多因素的，与年龄、感染持续时间、细菌菌株、宿主免疫状态有关。
