极稀的抗人IgE抗血清不会引发人嗜碱性粒细胞脱颗粒。

Human basophil degranulation is not triggered by very dilute antiserum against human IgE.

作者信息

Hirst S J, Hayes N A, Burridge J, Pearce F L, Foreman J C

机构信息

Department of Pharmacology, University College London, UK.

出版信息

Nature. 1993 Dec 9;366(6455):525-7. doi: 10.1038/366525a0.

DOI:10.1038/366525a0

PMID:8255290

Abstract

We have attempted to reproduce the findings of Benveniste and co-workers, who reported in 1988 that degranulation of human basophil leukocytes is triggered by very dilute (10(2)-10(120)) antiserum against IgE. The results were contrary to conventional scientific theory and were not satisfactorily explained. Following as closely as possible the methods of the original study, we can find no evidence for any periodic or polynomial change of degranulation as a function of anti-IgE dilution. Our results contain a source of variation for which we cannot account, but no aspect of the data is consistent with the previously published claims.

摘要

我们试图重现本韦尼斯特及其同事的研究结果，他们在1988年报告称，非常稀释（10⁻² - 10⁻¹²⁰）的抗IgE抗血清会引发人嗜碱性粒细胞的脱颗粒。这些结果与传统科学理论相悖，且未得到令人满意的解释。尽可能严格遵循原始研究的方法，我们找不到任何证据表明脱颗粒随抗IgE稀释度呈周期性或多项式变化。我们的结果包含一个无法解释的变异来源，但数据的任何方面都与先前发表的说法不一致。