Stress-induced immune suppression. Role of the autonomic nervous system.

Experimental data together with clinical studies have generated information about the association between sympathetic nervous system activity and immunity as measured by in vitro correlates of cellular immune function. In addition, studies on the in vivo role of central CRF in coordinating sympathetic outflow and modulating immune function have provided an opportunity to examine central mechanisms important in the link between brain, behavior, and immune function. Finally, use of CRF as a neuropeptide probe will likely continue to give information about the central mechanisms relevant to the abnormal regulation of sympathetic nervous activity and immune function in stress and possibly in aging.