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大肠杆菌和鼠伤寒沙门氏菌的oxyR调节子突变体对异烟肼的敏感性

Susceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid.

作者信息

Rosner J L

机构信息

Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892.

出版信息

Antimicrob Agents Chemother. 1993 Oct;37(10):2251-3. doi: 10.1128/AAC.37.10.2251.

DOI:10.1128/AAC.37.10.2251
PMID:8257155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC192262/
Abstract

Escherichia coli and Salmonella typhimurium are normally resistant to > 500 micrograms of the antituberculosis drug isonicotinic acid hydrazide (isoniazid; INH) per ml. Susceptibility to INH (< 50 micrograms/ml) has now been found for mutants that are deficient in OxyR, the oxidative stress response regulator. Two OxyR-regulated enzymes, alkyl hydroperoxide reductase and hydroperoxidase I, were identified as playing important roles in INH resistance. OxyR regulon mutants should be useful for identifying other determinants of INH resistance in both E. coli and Mycobacterium tuberculosis and for finding new INH-like drugs.

摘要

大肠杆菌和鼠伤寒沙门氏菌通常对每毫升超过500微克的抗结核药物异烟肼（INH）具有抗性。现在发现，对于缺乏氧化应激反应调节因子OxyR的突变体，它们对INH敏感（<50微克/毫升）。两种受OxyR调节的酶，烷基过氧化氢还原酶和过氧化氢酶I，被确定在对INH的抗性中起重要作用。OxyR调控子突变体对于鉴定大肠杆菌和结核分枝杆菌中INH抗性的其他决定因素以及寻找新的类INH药物应该是有用的。

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本文引用的文献

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Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations.用katG进行转化可恢复对一系列药物浓度耐药的结核分枝杆菌分离株的异烟肼敏感性。
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