大肠杆菌和鼠伤寒沙门氏菌的oxyR调节子突变体对异烟肼的敏感性
Susceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid.
作者信息
Rosner J L
机构信息
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892.
出版信息
Antimicrob Agents Chemother. 1993 Oct;37(10):2251-3. doi: 10.1128/AAC.37.10.2251.
Abstract
Escherichia coli and Salmonella typhimurium are normally resistant to > 500 micrograms of the antituberculosis drug isonicotinic acid hydrazide (isoniazid; INH) per ml. Susceptibility to INH (< 50 micrograms/ml) has now been found for mutants that are deficient in OxyR, the oxidative stress response regulator. Two OxyR-regulated enzymes, alkyl hydroperoxide reductase and hydroperoxidase I, were identified as playing important roles in INH resistance. OxyR regulon mutants should be useful for identifying other determinants of INH resistance in both E. coli and Mycobacterium tuberculosis and for finding new INH-like drugs.
摘要
大肠杆菌和鼠伤寒沙门氏菌通常对每毫升超过500微克的抗结核药物异烟肼（INH）具有抗性。现在发现，对于缺乏氧化应激反应调节因子OxyR的突变体，它们对INH敏感（<50微克/毫升）。两种受OxyR调节的酶，烷基过氧化氢还原酶和过氧化氢酶I，被确定在对INH的抗性中起重要作用。OxyR调控子突变体对于鉴定大肠杆菌和结核分枝杆菌中INH抗性的其他决定因素以及寻找新的类INH药物应该是有用的。
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1
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Mol Microbiol. 1993 May;8(3):521-4. doi: 10.1111/j.1365-2958.1993.tb01596.x.
2
Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis.结核分枝杆菌对异烟肼敏感性所需的过氧化氢酶-过氧化物酶编码基因katG的特征分析。
J Bacteriol. 1993 Jul;175(13):4255-9. doi: 10.1128/jb.175.13.4255-4259.1993.
3
Isolation of catalase-deficient Escherichia coli mutants and genetic mapping of katE, a locus that affects catalase activity.过氧化氢酶缺陷型大肠杆菌突变体的分离以及影响过氧化氢酶活性的基因座katE的遗传定位。
J Bacteriol. 1984 Feb;157(2):622-6. doi: 10.1128/jb.157.2.622-626.1984.
4
Gene in the major cotransduction gap of the Escherichia coli K-12 linkage map required for the expression of chromosomal resistance to tetracycline and other antibiotics.大肠杆菌K-12连锁图谱主要共转导间隙中的基因，该基因是染色体对四环素和其他抗生素产生抗性所必需的。
J Bacteriol. 1983 Aug;155(2):541-8. doi: 10.1128/jb.155.2.541-548.1983.
5
Construction and characterization of new cloning vehicles. IV. Deletion derivatives of pBR322 and pBR325.新型克隆载体的构建与特性分析。IV. pBR322和pBR325的缺失衍生物
Gene. 1980 May;9(3-4):287-305. doi: 10.1016/0378-1119(90)90328-o.
6
Genetic mapping of katF, a locus that with katE affects the synthesis of a second catalase species in Escherichia coli.katF的基因定位，katF是一个与katE共同影响大肠杆菌中第二种过氧化氢酶合成的基因座。
J Bacteriol. 1984 Nov;160(2):668-75. doi: 10.1128/jb.160.2.668-675.1984.
7
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Virology. 1972 Jun;48(3):679-89. doi: 10.1016/0042-6822(72)90152-3.
8
Nonheritable resistance to chloramphenicol and other antibiotics induced by salicylates and other chemotactic repellents in Escherichia coli K-12.水杨酸盐及其他趋化性排斥剂在大肠杆菌K-12中诱导产生的对氯霉素及其他抗生素的非遗传性抗性
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Physical characterization of katG, encoding catalase HPI of Escherichia coli.编码大肠杆菌过氧化氢酶HPI的katG的物理特性
Gene. 1987;52(2-3):121-8. doi: 10.1016/0378-1119(87)90038-2.
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Cell. 1985 Jul;41(3):753-62. doi: 10.1016/s0092-8674(85)80056-8.
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