高尔基体膜蛋白的靶向与滞留
Targeting and retention of Golgi membrane proteins.
作者信息
Machamer C E
机构信息
Department of Cell Biology and Anatomy, Johns Hopkins Medical School, Baltimore, Maryland 21205.
出版信息
Curr Opin Cell Biol. 1993 Aug;5(4):606-12. doi: 10.1016/0955-0674(93)90129-e.
Abstract
Recent cloning of genes encoding membrane proteins of the Golgi complex has allowed investigation of protein targeting to this organelle. Targeting signals have been identified in three glycosyltransferases, a viral envelope protein and several proteins of the trans-Golgi network. Interestingly, the targeting signals for membrane proteins of the Golgi stacks seem to be contained in transmembrane domains. Information in the cytoplasmic tails is required for the targeting of trans-Golgi network proteins. Mechanisms involving both retention and retrieval have been invoked.
摘要
最近对编码高尔基体复合体膜蛋白的基因进行克隆，使得对蛋白质靶向该细胞器的研究成为可能。在三种糖基转移酶、一种病毒包膜蛋白和反式高尔基体网络的几种蛋白质中已鉴定出靶向信号。有趣的是，高尔基体堆叠膜蛋白的靶向信号似乎包含在跨膜结构域中。反式高尔基体网络蛋白的靶向需要细胞质尾巴中的信息。已经提出了涉及保留和回收的机制。
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