胰岛素依赖型糖尿病合并格雷夫斯病和特发性甲状旁腺功能减退症。

Insulin-dependent diabetes mellitus associated with Graves' disease and idiopathic hypoparathyroidism.

作者信息

Yoshioka K, Ohsawa A, Yoshida T, Yokoh S

机构信息

First Department of Internal Medicine, Matsushita Memorial Hospital, Osaka, Japan.

出版信息

J Endocrinol Invest. 1993 Sep;16(8):643-6. doi: 10.1007/BF03347687.

DOI:10.1007/BF03347687

PMID:8258654

Abstract

We report a case of 26-year-old woman with Graves' disease and idiopathic hypoparathyroidism diagnosed at 11 years of age, who subsequently developed insulin-dependent diabetes mellitus (IDDM) at 17 years of age. Treatment with antithyroid agents had failed to control her Graves' disease and her IDDM was unmanageable despite insulin therapy. Surgical intervention was carried out, resulting in an improvement of both her hyperthyroidism and IDDM. This case is the first report of polyglandular autoimmune (PGA) syndrome, presenting the association of IDDM, Graves' disease and idiopathic hypoparathyroidism.

摘要

我们报告了一例26岁女性患者，该患者11岁时被诊断为格雷夫斯病和特发性甲状旁腺功能减退症，随后在17岁时发展为胰岛素依赖型糖尿病（IDDM）。抗甲状腺药物治疗未能控制她的格雷夫斯病，尽管进行了胰岛素治疗，她的IDDM仍难以控制。于是进行了手术干预，结果她的甲亢和IDDM均有所改善。该病例是多腺体自身免疫（PGA）综合征的首例报告，呈现了IDDM、格雷夫斯病和特发性甲状旁腺功能减退症的关联。