Campíns-Falcó P, Herráez-Hernández R, Sevillano-Cabeza A
Departamento de Química Analítica, Facultad de Química, Universidad de Valencia, Burjassot, Spain.
J Chromatogr. 1993 Sep 22;619(2):177-90. doi: 10.1016/0378-4347(93)80107-f.
In recent years, an increasing number of publications have demonstrated the potential of column-switching techniques for the chromatographic separation, determination and preparative isolation of analytes from biological matrices. Column-switching systems greatly facilitate drug analysis, by on-line sample clean-up and trace enrichment, or by improving the analytical separative process. In this paper, the main applications of column-switching techniques to drug analysis in biological samples, are reviewed.
近年来，越来越多的出版物表明了柱切换技术在从生物基质中对分析物进行色谱分离、测定和制备分离方面的潜力。柱切换系统通过在线样品净化和痕量富集，或通过改善分析分离过程，极大地促进了药物分析。本文综述了柱切换技术在生物样品药物分析中的主要应用。
