Greenspan S L, Myers E R, Maitland L A, Resnick N M, Hayes W C
Department of Medicine, Beth Israel Hospital, Boston, Mass 02215.
JAMA. 1994 Jan 12;271(2):128-33.
To determine the relative importance of fall characteristics, body habitus, and femoral bone mineral density (BMD) in predicting hip fracture in community-dwelling elderly.
Prospective case-control study.
Community-based academic hospital.
A total of 149 ambulatory, community-dwelling fallers (126 women, 23 men) aged 65 years and older, including 72 case patients (fallers with hip fracture) and 77 control fallers (fallers with no hip fracture).
Fall characteristics, body habitus, femoral BMD.
Significant and independent risk factors for hip fracture in both sexes were direction of the fall (adjusted odds ratio [OR], 5.7; 95% confidence interval [CI], 2.3 to 14.0; P < .001); femoral neck BMD (a decrease of 1 SD; adjusted OR, 2.7; 95% CI, 1.6 to 4.6; P < .001); potential energy of the fall (an increase of 1 SD; adjusted OR, 2.8; 95% CI, 1.5 to 5.2; P < .001); and body mass index (a decrease of 1 SD; adjusted OR, 2.2; 95% CI, 1.2 to 3.8; P < .01). Importantly, the OR for the fall direction was unaffected by the addition or removal of BMD from the model.
We conclude that among elderly fallers--in most of whom hip BMD is already less than the fracture threshold--fall characteristics and body habitus are important risk factors for hip fracture and touch on a domain entirely missed by knowledge of BMD. These data suggest new targets for preventive therapy. In addition to the maintenance of bone density, reductions in fall severity (eg, by use of trochanteric padding or enhancement of muscle strength) may provide additional strategies for prevention of hip fracture in this age group.
确定跌倒特征、身体体型和股骨骨密度(BMD)在预测社区居住老年人髋部骨折方面的相对重要性。
前瞻性病例对照研究。
社区学术医院。
共有149名65岁及以上的社区居住能走动的跌倒者(126名女性,23名男性),包括72例病例患者(髋部骨折的跌倒者)和77名对照跌倒者(无髋部骨折的跌倒者)。
跌倒特征、身体体型、股骨BMD。
男女髋部骨折的显著且独立的危险因素为跌倒方向(调整后的优势比[OR],5.7;95%置信区间[CI],2.3至14.0;P <.001);股骨颈BMD(降低1个标准差;调整后的OR,2.7;95%CI,1.6至4.6;P <.001);跌倒势能(增加1个标准差;调整后的OR,2.8;95%CI,1.5至5.2;P <.001);以及体重指数(降低1个标准差;调整后的OR,2.2;95%CI,1.2至3.8;P <.01)。重要的是,跌倒方向的OR不受模型中BMD的添加或去除的影响。
我们得出结论,在老年跌倒者中——他们大多数的髋部BMD已经低于骨折阈值——跌倒特征和身体体型是髋部骨折的重要危险因素,涉及到BMD知识完全遗漏的一个领域。这些数据提示了预防治疗的新靶点。除了维持骨密度外,降低跌倒严重程度(例如,通过使用转子衬垫或增强肌肉力量)可能为该年龄组预防髋部骨折提供额外的策略。