Thompson A J, Kermode A G, Moseley I F, MacManus D G, McDonald W I
NMR Research Group, Institute of Neurology, London, UK.
J Neurol Neurosurg Psychiatry. 1993 Dec;56(12):1317-20. doi: 10.1136/jnnp.56.12.1317.
The MRI data of seven patients with clinically definite multiple sclerosis who developed epileptic seizures are presented. Six of these cases demonstrated new or enhancing lesions. Cerebral biopsy in one of these lesions confirmed inflammation with myelin breakdown products. Lesions implicated in the causation of seizures involved the cortex or subcortical area. In one patient, a new lesion was associated with EEG abnormalities which resolved as the lesion reduced in size. In three patients epileptic activity was the only clinical manifestation of disease. Large, unresolving lesions tended to be associated with continuing seizures.
本文展示了7例临床确诊为多发性硬化且出现癫痫发作患者的MRI数据。其中6例出现新的或强化性病变。对其中一个病变进行脑活检证实存在伴有髓磷脂分解产物的炎症。与癫痫发作病因相关的病变累及皮质或皮质下区域。在1例患者中，一个新病变与脑电图异常相关，随着病变尺寸减小，脑电图异常也随之消失。在3例患者中，癫痫活动是疾病的唯一临床表现。较大且不消退的病变往往与持续性癫痫发作相关。
