Brantigan J W, Steffee A D
Department of Surgery, Division of Orthopaedics, Creighton University, Omaha, Nebraska.
Spine (Phila Pa 1976). 1993 Oct 15;18(14):2106-7. doi: 10.1097/00007632-199310001-00030.
The success of posterior lumbar interbody fusion (PLIF) has been limited by mechanical and biologic deficiencies of the donor bone. The authors have designed a carbon fiber-reinforced polymer implant that separates the mechanical and biologic functions of PLIF. The cagelike implant provides an actual device designed to meet the mechanical requirements of PLIF and replaces the donor bone with autologous bone, the best possible bone for healing. The authors report 2-year follow-up results for their first 26 consecutive patients, 18 of whom were postsurgical failed backs with a total of 37 previous surgeries. At 2 years, 28 of 28 PLIF cage fusion levels and 6 of 11 (54.5%) allograft levels exhibited radiographic fusion, a statistically significant difference at P = 0.0002. Clinical results were excellent in 11/26, good in 10/26, fair in 3/26, and poor in 2/26. Fair and poor results were attributable to objective identifiable problems unrelated to the carbon cage. The carbon implant achieved successful fusion in 6/6 (100%) of followed patients treated for a failed ETO allograft interbody fusion. A prospective controlled multi-centered study is being initiated.
后路腰椎椎间融合术（PLIF）的成功受到供体骨机械和生物学缺陷的限制。作者设计了一种碳纤维增强聚合物植入物，将PLIF的机械和生物学功能分开。这种笼状植入物提供了一种实际装置，旨在满足PLIF的机械要求，并用自体骨替代供体骨，自体骨是愈合的最佳骨材料。作者报告了他们连续26例患者的2年随访结果，其中18例为术后背部失败患者，之前总共接受了37次手术。2年后，28个PLIF椎间融合器融合节段中的28个以及11个同种异体骨移植节段中的6个（54.5%）显示影像学融合，P = 0.0002，具有统计学显著差异。临床结果为：优11/26，良10/26，可3/26，差2/26。可和差的结果归因于与碳笼无关的客观可识别问题。对于接受失败的ETO同种异体骨椎间融合术治疗的随访患者，碳植入物在6/6（100%）的患者中实现了成功融合。一项前瞻性对照多中心研究正在启动。
