补体裂解产物C3a的细胞溶解作用。
Cytolytic effects of the complement cleavage product, C3a.
作者信息
Ferluga J, Schorlemmer H U, Baptista L C, Allison A C
出版信息
Br J Cancer. 1976 Dec;34(6):626-34. doi: 10.1038/bjc.1976.223.
Abstract
Purified C3a, a cleavage product of the third component of complement,was incubated with various cell types of human and mouse origin. All the tumour cell types tested were lysed by low concentrations of C3a, whereas normal human lymphocytes were relatively resistant. No lysis was produced by C3 or C3b. The possible role of C3a in immunity against tumours is discussed.
摘要
补体第三成分的裂解产物纯化C3a与人和小鼠来源的多种细胞类型一起孵育。所有测试的肿瘤细胞类型都被低浓度的C3a裂解，而正常人淋巴细胞相对耐药。本文讨论了C3a在抗肿瘤免疫中的可能作用。
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