Robinson R J, Royston D
Department of Histopathology, Beaumont Hospital, Dublin, Ireland.
Cytopathology. 1993;4(5):267-71. doi: 10.1111/j.1365-2303.1993.tb00101.x.
Commercially available monoclonal antibodies AUA1, BER EP4 and carcinoembryonic antigen (CEA) were applied to cell blocks from 95 serous effusions. AUA1 and BER EP4 were reactive with 89% of effusions known to contain carcinoma cells, and anti-CEA with 71%. They also reacted with cells in two effusions from patients with malignant disease which were regarded as negative on conventional cytological examination of Papanicolaou-stained smears. They were negative in all but one of the benign effusions. Using all three antibodies, 95% of effusions containing carcinoma cells were detected. Use of these antibodies could improve the cytological diagnosis of serous effusions.
将市售单克隆抗体AUA1、BER EP4和癌胚抗原（CEA）应用于95例浆液性积液的细胞块。AUA1和BER EP4与已知含有癌细胞的89%的积液有反应，抗CEA与71%的积液有反应。它们还与恶性疾病患者的两例积液中的细胞发生反应，而这些积液在巴氏染色涂片的传统细胞学检查中被视为阴性。除一例良性积液外，它们在所有良性积液中均为阴性。使用这三种抗体，检测到了95%含有癌细胞的积液。使用这些抗体可以改善浆液性积液的细胞学诊断。
