Babor T F, Mendelson J H, Kuehnle J
Psychopharmacology (Berl). 1976 Oct 20;50(1):11-9. doi: 10.1007/BF00634148.
Adult male volunteers with a prior history of either moderate (N = 12) or heavy (N = 14) marihuana use were systematically observed before, during and after a 21-day period of free access to 1 g 2% delta-9 THC marihuana cigarettes. A matched sample of casual alcohol drinkers (N = 11) served as a control group. Sleep and other molar behaviors were observed hourly to obtain a representative sample of daily activity. Both moderate and heavy users were less active immediately after marihuana use and slept more on days following heavier consumption. Heavy users reduced their waking activity on days following heavier consumption, as well as during the entire period of marihuana availability. These reactions did not persist beyond the period of availability for either group. The findings suggest a dose-related delayed reaction to heavy marihuana consumption which disappears following the cessation of regular use. However, changes in activity following single doses of marihuana may be related more to the social circumstances of its use than to its pharmacological action.
对有中度（N = 12）或重度（N = 14）大麻使用史的成年男性志愿者，在给予其21天自由接触含1克2% Δ-9 四氢大麻酚的大麻卷烟的前后及期间进行了系统观察。选取一组匹配的偶尔饮酒者（N = 11）作为对照组。每小时观察睡眠及其他总体行为，以获取日常活动的代表性样本。中度和重度使用者在吸食大麻后立即活动减少，且在吸食量较大后的几天睡眠增多。重度使用者在吸食量较大后的几天以及整个可获取大麻的期间，清醒时的活动量都减少了。这些反应在两组的可获取期之后都没有持续。研究结果表明，对大量吸食大麻存在与剂量相关的延迟反应，在停止经常使用后这种反应会消失。然而，单次吸食大麻后活动的变化可能更多地与其使用的社会环境有关，而非其药理作用。
