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攻击性精神病患者体内苯乙胺过量分泌。

Phenylethylamine overproduction in aggressive psychopaths.

作者信息

Sandler M, Ruthven C R, Goodwin G L, Field H, Matthews R

出版信息

Lancet. 1978 Dec 16;2(8103):1269-70. doi: 10.1016/s0140-6736(78)92037-8.

DOI:10.1016/s0140-6736(78)92037-8
PMID:82778
Abstract

Plasma concentrations of free and conjugated phenylacetic acid, the major metabolite of phenylethylamine, were higher in ten prisoners serving long terms of imprisonment for violent crimes than in pair-matched non-violent control prisoners. Since amphetamine, a compound closely related to phenylethylamine, can reduce aggressiveness in some violent subjects, the increase in phenylethylamine production may be an attempt to compensate for the unknown derangement of function responsible for increased aggression.

摘要

苯乙胺的主要代谢产物——游离型和结合型苯乙酸的血浆浓度,在十名因暴力犯罪而长期服刑的囚犯中,高于配对的非暴力对照囚犯。由于与苯乙胺密切相关的化合物安非他命可降低一些暴力受试者的攻击性,苯乙胺生成增加可能是一种试图补偿导致攻击性增加的未知功能紊乱的尝试。

相似文献

1
Phenylethylamine overproduction in aggressive psychopaths.攻击性精神病患者体内苯乙胺过量分泌。
Lancet. 1978 Dec 16;2(8103):1269-70. doi: 10.1016/s0140-6736(78)92037-8.
2
Trace acid levels in the plasma and MAO activity in the platelets of violent offenders.
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Phenylacetic acid in human body fluids: high correlation between plasma and cerebrospinal fluid concentration values.人体体液中的苯乙酸:血浆与脑脊液浓度值之间高度相关。
J Neurol Neurosurg Psychiatry. 1982 Apr;45(4):366-8. doi: 10.1136/jnnp.45.4.366.
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Effect of dietary phenylalanine on the plasma concentrations of phenylalanine, phenylethylamine and phenylacetic acid in healthy volunteers.饮食中苯丙氨酸对健康志愿者血浆中苯丙氨酸、苯乙胺和苯乙酸浓度的影响。
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Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplements.情感障碍苯乙胺假说的临床研究:尿液和血液中的苯乙酸及苯丙氨酸膳食补充剂
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Phenylacetic acid production in dominant and non-dominant vervet monkeys.优势种和非优势种黑长尾猴中苯乙酸的产生
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Self-reported trauma, cortisol levels, and aggression in psychopathic and non-psychopathic prison inmates.有精神病态和无精神病态的监狱囚犯的自我报告创伤、皮质醇水平及攻击性
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Alterations in trace amine and trace acid concentrations in isolated aggressive mice.分离出的攻击性小鼠体内痕量胺和痕量酸浓度的变化。
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Role of sex hormone-binding globulin in the relationship between sex hormones and antisocial and aggressive personality in inmates.性激素结合球蛋白在性激素与囚犯反社会及攻击型人格关系中的作用。
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Some aspects of basic psychopharmacology: the trace amines.基础精神药理学的某些方面:痕量胺。
Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(4-6):563-70. doi: 10.1016/s0278-5846(82)80150-4.

引用本文的文献

1
Platelet abnormalities in aggressive subjects with mental deficiency.患有智力缺陷的攻击性个体的血小板异常。
J Psychiatry Neurosci. 1996 Mar;21(2):109-13.
2
Phenylacetic acid in human body fluids: high correlation between plasma and cerebrospinal fluid concentration values.人体体液中的苯乙酸:血浆与脑脊液浓度值之间高度相关。
J Neurol Neurosurg Psychiatry. 1982 Apr;45(4):366-8. doi: 10.1136/jnnp.45.4.366.
3
Cerebral decarboxylation of meta- and para-tyrosine.间位和对位酪氨酸的脑内脱羧作用。
Experientia. 1983 Feb 15;39(2):130-4. doi: 10.1007/BF01958860.
4
Urinary phenylethylamine correlates positively with hypomania, and negatively with depression, paranoia, and social introversion on the MMPI.尿中苯乙胺与轻躁狂呈正相关,与明尼苏达多相人格调查表(MMPI)上的抑郁、偏执和社交内向呈负相关。
Eur Arch Psychiatry Neurol Sci. 1986;236(2):83-7. doi: 10.1007/BF00454016.