Opportunistic infections in AIDS patients. Current management and prevention.

The number of drugs available for treatment and prevention of opportunistic infections in patients who are seropositive for HIV infection is limited, although some agents currently being studied show promise. Pneumocystis carinii pneumonia, the most common opportunistic infection, can be effectively managed, although prophylaxis must be continued indefinitely. Because an increased incidence of tuberculosis is associated with HIV infection, the emergence of strains that are resistant to multiple drugs is of concern. Intensive therapy with five or six drugs may be necessary. Isoniazid (Nydrazid) is recommended for prophylaxis.