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肺癌病例对照研究中被动吸烟暴露史的可靠性

Reliability of passive smoke exposure histories in a case-control study of lung cancer.

作者信息

Brownson R C, Alavanja M C, Hock E T

机构信息

Division of Chronic Disease Prevention and Health Promotion, Missouri Department of Health, Columbia 65203.

出版信息

Int J Epidemiol. 1993 Oct;22(5):804-8. doi: 10.1093/ije/22.5.804.

DOI:10.1093/ije/22.5.804
PMID:8282458
Abstract

Despite the growing number of studies on the health effects of passive smoke exposure, few data exist on the quality of questionnaire data on passive smoking. To measure the reliability of passive smoking histories, re-interviews were conducted for 110 subjects (37 cases and 73 controls) as part of a larger study of lung cancer among non-smoking women in Missouri. Agreement was high both for parental smoking status (94% concordance; kappa = 0.82) and for spousal smoking status (84% concordance; kappa = 0.67). Concordance also was relatively high for cigarette pack-years of exposure due to the parents or spouse. Reliability tended to be somewhat higher among controls than among cases, and for exposure due to a parent or spouse than for that due to other household members. Questions on the perceived harmfulness of passive smoke exposure showed no differences between cases and controls. These findings indicate a high degree of repeatability in responses regarding passive smoking, but also suggest the potential for misclassification of passive smoke exposure status, the desirability of standardized questions on passive smoking, and the need for additional studies of reliability and validity.

摘要

尽管关于被动吸烟对健康影响的研究越来越多,但关于被动吸烟问卷调查数据质量的数据却很少。为了衡量被动吸烟史的可靠性,作为对密苏里州非吸烟女性肺癌的一项更大规模研究的一部分,对110名受试者(37例病例和73名对照)进行了再次访谈。父母吸烟状况(一致性为94%;kappa值=0.82)和配偶吸烟状况(一致性为84%;kappa值=0.67)的一致性都很高。由于父母或配偶导致的香烟包年暴露量的一致性也相对较高。对照组的可靠性往往比病例组略高,因父母或配偶导致的暴露比因其他家庭成员导致的暴露的可靠性更高。关于被动吸烟感知危害的问题在病例组和对照组之间没有差异。这些发现表明在被动吸烟反应方面具有高度的可重复性,但也表明被动吸烟暴露状况可能存在错误分类,需要有关于被动吸烟的标准化问题,以及需要对可靠性和有效性进行更多研究。

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