Fantin B, Leclercq R, Duval J, Carbon C
Institut National de la Santé et de la Recherche Médicale, Unité 13, Service de Médecine Interne, Hôpital Bichat, Paris, France.
Antimicrob Agents Chemother. 1993 Nov;37(11):2466-9. doi: 10.1128/AAC.37.11.2466.
The usefulness of fusidic acid, alone or combined with vancomycin, was investigated for the therapy of experimental endocarditis caused in rabbits by a methicillin-resistant strain of Staphylococcus aureus. In vitro killing curves showed an indifferent interaction between the two antibiotics. In vivo, vancomycin alone was as effective as a vancomycin-fusidic acid combination (P < 0.05 versus control animals). No resistance to fusidic acid emerged during combination therapy. Fusidic acid alone was not effective. Resistance emerged in 5 of 12 animals treated with fusidic acid alone and was responsible for antibacterial failure. Fusidic acid alone was effective (P < 0.001) and did not select resistant strains if therapy was started when animals retained a smaller inoculum. We concluded that the vancomycin-fusidic acid combination exhibited no advantage over vancomycin alone in this model.
研究了单独使用夫西地酸或与万古霉素联合使用对耐甲氧西林金黄色葡萄球菌菌株引起的兔实验性心内膜炎的治疗效果。体外杀菌曲线显示这两种抗生素之间无协同作用。在体内，单独使用万古霉素与万古霉素 - 夫西地酸联合使用效果相同（与对照动物相比，P < 0.05）。联合治疗期间未出现对夫西地酸的耐药性。单独使用夫西地酸无效。单独使用夫西地酸治疗的12只动物中有5只出现耐药性，这是抗菌治疗失败的原因。如果在动物接种量较小时开始治疗，单独使用夫西地酸是有效的（P < 0.001）且不会选择耐药菌株。我们得出结论，在该模型中，万古霉素 - 夫西地酸联合使用并不比单独使用万古霉素更具优势。
