针对接受环丙沙星治疗的中性粒细胞减少患者的草绿色链球菌血培养分离株，潜在治疗性和预防性抗生素的活性。
Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin.
作者信息
McWhinney P H, Patel S, Whiley R A, Hardie J M, Gillespie S H, Kibbler C C
机构信息
Department of Microbiology, Royal Free Hospital School of Medicine, London, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1993 Nov;37(11):2493-5. doi: 10.1128/AAC.37.11.2493.
Abstract
All 47 sequential blood culture isolates of viridans group streptococci obtained from febrile neutropenic patients receiving quinolone prophylaxis were susceptible to vancomycin, teicoplanin, and imipenem. Resistance to benzylpenicillin (MIC for 50% of isolates [MIC50], 0.125 microgram/ml) and ceftazidime (MIC50, 4 micrograms/ml) was common. Most isolates were susceptible to amoxicillin, co-amoxiclav (amoxicillin-clavulanic acid at a 2:1 ratio by weight), azlocillin, clarithromycin, and erythromycin, with azithromycin showing comparable activity. The MIC90 of sparfloxacin was 1 microgram/ml; those for ciprofloxacin and ofloxacin were > 16 and 16 micrograms/ml, respectively.
摘要
从接受喹诺酮预防治疗的发热性中性粒细胞减少患者中获得的47株连续性草绿色链球菌血培养分离株，对万古霉素、替考拉宁和亚胺培南均敏感。对苄青霉素（50%分离株的MIC[MIC50]，0.125微克/毫升）和头孢他啶（MIC50，4微克/毫升）耐药很常见。大多数分离株对阿莫西林、阿莫西林克拉维酸（按重量比2:1的阿莫西林-克拉维酸）、阿洛西林、克拉霉素和红霉素敏感，阿奇霉素显示出相当的活性。司帕沙星的MIC90为1微克/毫升；环丙沙星和氧氟沙星的MIC90分别>16和16微克/毫升。
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1
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2
Resistance in oral streptococci after repeated three-dose erythromycin prophylaxis.重复三剂红霉素预防后口腔链球菌的耐药性。
J Antimicrob Chemother. 1985 Apr;15(4):471-9. doi: 10.1093/jac/15.4.471.
3
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Infection. 1989 Jul-Aug;17(4):240-4. doi: 10.1007/BF01639528.
4
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5
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6
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7
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8
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