尽管大鼠肿瘤的血流和组织氧合发生了显著变化，但生物能量状态仍保持稳定。
Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour.
作者信息
Vaupel P, Kelleher D K, Engel T
机构信息
Institute of Physiology & Pathophysiology, University of Mainz, Germany.
出版信息
Br J Cancer. 1994 Jan;69(1):46-9. doi: 10.1038/bjc.1994.7.
Experiments on s.c. rat tumours (DS sarcoma) were performed to determine whether chronic or acute changes in tumour perfusion necessarily lead to changes in tissue oxygenation and bioenergetic status since, as a rule, blood flow is thought to be the ultimate determinant of the tumour bioenergetic status. Based on this study, there is clear experimental evidence that growth-related or acute (following i.v. administration of tumour necrosis factor alpha) decreases in tumour blood flow are accompanied by parallel alterations in tissue oxygenation. In contrast, tumour energy status remains stable as long as flow values do not fall below 0.4-0.5 ml g-1 min-1, and provided that glucose as the main substrate can be recruited from the enlarged interstitial compartment. Perfusion rate seems to play a paramount role in determining energy status only in low-flow tumours or low-flow tissue areas.
对皮下大鼠肿瘤（DS肉瘤）进行了实验，以确定肿瘤灌注的慢性或急性变化是否必然导致组织氧合和生物能量状态的改变，因为通常认为血流是肿瘤生物能量状态的最终决定因素。基于这项研究，有明确的实验证据表明，与生长相关的或急性的（静脉注射肿瘤坏死因子α后）肿瘤血流减少伴随着组织氧合的平行改变。相比之下，只要血流值不低于0.4-0.5 ml g-1 min-1，并且只要可以从扩大的间质区募集葡萄糖作为主要底物，肿瘤能量状态就保持稳定。灌注率似乎仅在低血流肿瘤或低血流组织区域中在确定能量状态方面起至关重要的作用。
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