Kaukonen K, Savolainen J, Nermes M, Viander M, Terho E O
Department of Clinical Allergology, University of Turku, Finland.
Int Arch Allergy Immunol. 1997 Mar;112(3):313-6. doi: 10.1159/000237472.
IgG and IgA antibodies against fungus Aspergillus umbrosus have been found in the sera of patients with farmer's lung (FL) disease and healthy exposed farmers in Finland. To determine the IgE response to antigens of A. umbrosus and Candida albicans, sera from 20 patients with FL, 20 healthy farmers and 20 nonfarming controls were tested by nitrocellulose radioallergosorbent test (RAST). The values of RAST indices were low in each group and the only statistically significant difference was found between the groups of FL patients and nonfarming controls against A. umbrosus polysaccharide antigen. Individual IgE responses to polysaccharide antigens of A. umbrosus and C. albicans correlated among FL patients, however, no cross-reacting IgE antibodies could be shown. To conclude, the IgE antibody levels of A. umbrosus polysaccharide and crude antigens were low in FL patients, healthy exposed farmers and nonfarming controls. Neither polysaccharide nor crude antigen-specific IgE antibodies of A. umbrosus have any diagnostic value in FL disease.
在芬兰，已在农民肺（FL）病患者以及接触过相关物质的健康农民血清中发现了针对荫蔽曲霉的IgG和IgA抗体。为了确定对荫蔽曲霉和白色念珠菌抗原的IgE反应，采用硝酸纤维素放射变应原吸附试验（RAST）检测了20例FL患者、20名健康农民和20名非务农对照者的血清。每组的RAST指数值都很低，并且仅在FL患者组和非务农对照者组之间发现了针对荫蔽曲霉多糖抗原的具有统计学意义的差异。在FL患者中，个体对荫蔽曲霉和白色念珠菌多糖抗原的IgE反应存在相关性，然而，未发现交叉反应性IgE抗体。总之，FL患者、接触过相关物质的健康农民和非务农对照者中，荫蔽曲霉多糖和粗抗原的IgE抗体水平都很低。荫蔽曲霉的多糖和粗抗原特异性IgE抗体在FL疾病中均无任何诊断价值。
