Lim J I, Enger C, Fine S L
Wilmer Ophthalmological Institute, Department of Ophthalmology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Am J Ophthalmol. 1994 Jan 15;117(1):1-6. doi: 10.1016/s0002-9394(14)73007-7.
We reviewed the clinical records of 47 patients (92 eyes) at the Wilmer Institute in whom foveomacular dystrophy had been diagnosed between 1977 and 1990 to determine reasons for initial examination, long-term visual prognosis, and the factors associated with visual loss. From each clinical record, we obtained the patient's age at the time first seen, symptoms, initial and final visual acuity, lesion size and appearance, and results of fluorescein angiography, electroretinography, and electro-oculography. The most common reasons for examination were decreased visual acuity in 25 of the 47 patients (53%), metamorphopsia in six (13%), referral for diagnosis in seven (15%), and misdiagnosis of age-related macular degeneration in seven (15%). Over an average follow-up period of 5.0 years, in 29 patients (56 eyes), visual acuity changed less than two lines in 41 eyes and decreased greater than or equal to two lines in 15 eyes. In most patients with foveomacular dystrophy, visual acuity appears to remain relatively stable.
我们回顾了威尔默眼科研究所47例（92只眼）患者的临床记录，这些患者在1977年至1990年间被诊断为黄斑中心凹营养不良，以确定初诊原因、长期视力预后以及与视力丧失相关的因素。从每份临床记录中，我们获取了患者首次就诊时的年龄、症状、初始和最终视力、病变大小和外观，以及荧光素血管造影、视网膜电图和眼电图的结果。最常见的检查原因是47例患者中有25例（53%）视力下降，6例（13%）有视物变形，7例（15%）因诊断需求转诊，7例（15%）被误诊为年龄相关性黄斑变性。在平均5.0年的随访期内，29例患者（56只眼）中，41只眼的视力变化小于两行，15只眼的视力下降大于或等于两行。在大多数黄斑中心凹营养不良患者中，视力似乎保持相对稳定。
