Battaglia Parodi M, Iustulin D, Russo D, Ravalico G
Eye Clinic, University of Trieste, Italy.
Graefes Arch Clin Exp Ophthalmol. 1996 Mar;234(3):208-11. doi: 10.1007/BF00462035.
Adult-onset foveomacular vitelliform dystrophy (AOFVD) represents a heterogeneous group of disorders with different clinical, angiographic, and histopathological features. The most common form is characterized by a yellow, round to oval subretinal macular lesion with or without central pigmented spot.
Eight patients affected by typical AOFVD underwent fluorescein angiography and indocyanine green videoangiography (ICGV).
Fluorescein angiography showed a central hypofluorescent spot surrounded by an irregular hyperfluorescent ring. ICGV demonstrated a foveal nonfluorescent spot, visible during the entire examination, and a hyperfluorescent area surrounding the central spot, which became evident soon after the beginning of the examination.
In light of previous histopathological studies, the central nonfluorescent spot may be interpreted as a masking effect of a pigment clump, whereas the hyper-fluorescent area may represent dye pooling or staining of the subretinal pigment epithelial material.
成人型黄斑中心凹卵黄样营养不良（AOFVD）是一组具有不同临床、血管造影和组织病理学特征的异质性疾病。最常见的形式表现为视网膜下黄斑区有一个黄色、圆形至椭圆形病变，有或无中央色素沉着斑。
8例典型AOFVD患者接受了荧光素血管造影和吲哚菁绿视频血管造影（ICGV）检查。
荧光素血管造影显示中央低荧光斑被不规则高荧光环围绕。ICGV显示黄斑中心凹无荧光斑，在整个检查过程中可见，以及围绕中央斑的高荧光区，在检查开始后不久变得明显。
根据以往的组织病理学研究，中央无荧光斑可解释为色素团块的掩盖效应，而高荧光区可能代表染料积聚或视网膜下色素上皮物质的染色。
