Ellingsen D G, Thomassen Y, Langård S, Kjuus H
Department of Occupational Medicine, Telemark Central Hospital, Porsgrunn, Norway.
Scand J Work Environ Health. 1993 Oct;19(5):334-41. doi: 10.5271/sjweh.1466.
Seventeen former chloralkali workers were followed through the regular determination of urinary mercury for nearly two years after the cessation of exposure to mercury vapor in a study of the time course of urinary mercury elimination. Their duration of exposure ranged from 3 d to 35.5 years. A one-compartment model for urinary mercury elimination was applied. The urinary mercury concentration declined at a rate indicating a half-time of 91 d. When corrected for an individual base-line level of urinary mercury resulting from sources of mercury intake not related to work, the half-time was 72.4 [95% confidence interval (95% CI) 63.2-81.7] d, with a mean elimination rate constant of 0.011 (95% CI 0.008-0.013).d-1. The day-to-day variability of the urinary mercury concentration averaged 22%, expressed as the coefficient of variation between urine samples delivered on three consecutive days.
在一项关于尿汞排出时间进程的研究中，对17名曾接触汞蒸气的前氯碱工人在停止接触汞蒸气后进行了近两年的尿汞定期测定。他们的接触时长从3天到35.5年不等。应用了一个尿汞排出的一室模型。尿汞浓度下降速率表明半衰期为91天。当校正由与工作无关的汞摄入源导致的个体尿汞基线水平后，半衰期为72.4 [95%置信区间（95%CI）63.2 - 81.7]天，平均消除速率常数为0.011（95%CI 0.008 - 0.013）d⁻¹。尿汞浓度的每日变异性平均为22%，以连续三天送检的尿样间变异系数表示。
