Elhassan I M, Satti G H, Ali A E, Fadul I, Elkhalifa A A, Abedelrahim A M, Ming C, Theander T G
Centre for Medical Parasitology, University of Copenhagen, Denmark.
Trans R Soc Trop Med Hyg. 1993 Nov-Dec;87(6):685-6. doi: 10.1016/0035-9203(93)90293-y.
The efficacy of artemether (a qinghaosu derivative) administered intramuscularly for the treatment of Plasmodium falciparum malaria was compared to quinine in an open randomized trial including 54 patients in eastern Sudan, where chloroquine resistance is common. The artemether treatment (5 d intramuscular regimen) was effective and the drug was well tolerated. All patients had cleared the parasitaemia and were free of symptoms 48 h after initiation of treatment. The parasite clearance time was comparable in patients receiving artemether and quinine. No side effect was reported by patients receiving artemether. No recrudescence was seen in 21 patients treated with artemether who completed 28 d follow-up. In the quinine group 3 of 18 patients had recrudescences, or possibly reinfections, on days 14, 21 and 28.
在苏丹东部进行的一项开放性随机试验中，将肌肉注射蒿甲醚（一种青蒿素衍生物）治疗恶性疟原虫疟疾的疗效与奎宁进行了比较。该试验纳入了54名患者，当地氯喹耐药情况常见。蒿甲醚治疗（5天肌肉注射方案）有效且药物耐受性良好。所有患者在开始治疗48小时后疟原虫血症均已清除且无症状。接受蒿甲醚和奎宁治疗的患者的寄生虫清除时间相当。接受蒿甲醚治疗的患者未报告有副作用。在完成28天随访的21名接受蒿甲醚治疗的患者中未出现复发情况。在奎宁组中，18名患者中有3名在第14、21和28天出现了复发或可能的再感染。
