Geddes M, Franceschi S, Barchielli A, Falcini F, Carli S, Cocconi G, Conti E, Crosignani P, Gafà L, Giarelli L
Servizio di Epidemiologia Descrittiva, Valutativa e di Cancerogenesi Ambientale, Sezione dell'IST di Genova, Italy.
Br J Cancer. 1994 Feb;69(2):333-6. doi: 10.1038/bjc.1994.60.
The incidence of Kaposi's sarcoma (KS) in 1976-90 was assessed in Italy, taking advantage of a network of nine population-based cancer registries covering, at its maximum, approximately 5.6 million subjects. The first examined period (1976-84) substantially reflects the epidemiology of KS prior to the AIDS epidemic in the registration areas. Elevated incidence rates, standardised to the Italian population of 1981, of 1.05/100,000 men and 0.27/100,000 women emerged in 1976-84 (i.e. from two- to threefold higher than in the USA and Sweden, more than tenfold higher than in England and Wales). These high rates, especially remarkable in the Registry from the south of Italy (i.e. Ragusa, 3.01/100,000 men and 0.54/100,000 women) suggest that the prevalence of the still unknown causative agent for KS was high, at least in some parts of Italy, prior to the AIDS epidemic. In the most recent period (1985-90), an approximately twofold increase in KS incidence rates in Italian men below age 50 was observed (from 0.15 in 1976-84 to 0.47 in 1985-90). Conversely, declines in KS incidence were recorded in older men.
利用一个由九个基于人群的癌症登记处组成的网络，对1976年至1990年期间意大利卡波西肉瘤（KS）的发病率进行了评估，该网络最多覆盖约560万人口。第一个研究期（1976 - 1984年）基本反映了登记地区艾滋病流行之前KS的流行病学情况。1976年至1984年期间，按照1981年意大利人口进行标准化后，男性发病率为1.05/10万，女性发病率为0.27/10万（即比美国和瑞典高出两到三倍，比英格兰和威尔士高出十多倍）。这些高发病率，在意大利南部的登记处（即拉古萨，男性为3.01/10万，女性为0.54/10万）尤为显著，表明在艾滋病流行之前，至少在意大利的某些地区，KS的未知致病因素的流行率很高。在最近一个时期（1985 - 1990年），观察到50岁以下意大利男性的KS发病率大约增加了两倍（从1976 - 1984年的0.15增加到1985 - 90年的0.47）。相反，老年男性的KS发病率有所下降。
