Wang X J
Neuroreport. 1993 Dec 13;5(3):221-4. doi: 10.1097/00001756-199312000-00008.
We present a biophysical model of a slowly inactivating potassium ion current IKS, based on recent voltage-clamp data from layer V pyramidal neurons in the cat sensorimotor cortex and show that the interplay between a persistent sodium current INaP and IKS is able to produce intrinsic membrane potential oscillations in the 10- to 50-frequency range. A most notable characteristic of such rhythmicity is what may be termed mixed-mode bursting, where clusters of action potentials alternate in time with epochs of small subthreshold oscillations.
我们基于猫感觉运动皮层V层锥体神经元最近的电压钳数据，提出了一种缓慢失活钾离子电流IKS的生物物理模型，并表明持续性钠电流INaP和IKS之间的相互作用能够产生10至50频率范围内的内在膜电位振荡。这种节律性最显著的特征可能是所谓的混合模式爆发，即动作电位簇与小的阈下振荡时期在时间上交替出现。
