Ichimura K, Ohno K, Aoyagi M, Tamaki M, Suzuki R, Hirakawa K
Department of Neurosurgery, Tokyo Medical and Dental University, Japan.
J Neurooncol. 1993 Jun;16(3):211-5. doi: 10.1007/BF01057035.
We have examined the capillary permeability within and adjacent to experimental rat gliomas, and the effect of intracarotid administration of cisplatin in this model. Permeability to 14C-sucrose was 25-fold and six-fold higher within the brain tumor and in the tumor periphery and adjacent tissue respectively than in the normal cortex. Intracarotid administration of cisplatin resulted in ten-fold increase in experimental gliomas and also a significant increase in the tumor periphery and adjacent tissue, when compared to the intravenous route. Intracarotid administration of cisplatin to rat did not cause acute vascular damage in either the brain or brain tumor at the dosage used.
我们研究了实验性大鼠胶质瘤内部及周边的毛细血管通透性，以及在该模型中颈内动脉注射顺铂的效果。脑肿瘤内部、肿瘤周边及相邻组织对14C-蔗糖的通透性分别比正常皮质高25倍和6倍。与静脉途径相比，颈内动脉注射顺铂使实验性胶质瘤的通透性增加了10倍，肿瘤周边及相邻组织的通透性也显著增加。以所用剂量对大鼠进行颈内动脉注射顺铂，在大脑或脑肿瘤中均未造成急性血管损伤。
