Simon B R, Kaufmann M V, McAfee M A, Baldwin A L
Department of Aerospace and Mechanical Engineering, University of Arizona, Tucson 85721.
J Biomech Eng. 1993 Nov;115(4B):489-96. doi: 10.1115/1.2895529.
Arterial wall mechanics has been studied for nearly 200 years. This subject is of importance if we are to gain a fundamental understanding of this complex biological structure, as well as information needed to design prosthetics. Biomechanical arterial models continue to play an important role in the study of atherosclerosis, a disease of the arterial wall that is the chief cause of mortality and morbidity in the United States and the Western World. Over the past 20 years, the finite element model (FEM) has been used in a variety of ways to simulate the structural response of large arteries. Our purpose is to summarize the uses of FEMs in arterial mechanics. We will also indicate directions for future research in this area. A specialized FEM was described in the literature for the study of transport in the arterial wall, however the convection was not directly linked to arterial wall mechanics. In this paper special attention will be given to the development of FEMs based on the poroelastic view of arterial tissues which couple wall deformation, free tissue fluid motion, and associated transport phenomena in the arterial wall. In the future such models should provide fundamental quantitative information relating arterial wall mechanics and transport which may lead to a better understanding of both normal arterial physiology and atherogenesis.
动脉壁力学已经被研究了近200年。如果我们想要对这个复杂的生物结构有一个基本的了解，以及获得设计假肢所需的信息，那么这个课题就很重要。生物力学动脉模型在动脉粥样硬化的研究中继续发挥着重要作用，动脉粥样硬化是一种动脉壁疾病，是美国和西方世界死亡和发病的主要原因。在过去的20年里，有限元模型（FEM）已经被以各种方式用于模拟大动脉的结构反应。我们的目的是总结有限元模型在动脉力学中的应用。我们还将指出该领域未来的研究方向。文献中描述了一种专门用于研究动脉壁内物质传输的有限元模型，然而对流并未与动脉壁力学直接相关。在本文中，将特别关注基于动脉组织多孔弹性观点的有限元模型的发展，这种模型将壁变形、自由组织液运动以及动脉壁内相关的传输现象耦合在一起。未来，这样的模型应该能够提供有关动脉壁力学和传输的基本定量信息，这可能有助于更好地理解正常动脉生理学和动脉粥样硬化的发生机制。
