Arabidze G G, Rogoza A N, Dmitriev V V, Metelitsa T V, Domba G Iu, Sitina V K
Ter Arkh. 1993;65(9):50-2.
To elucidate a hypotensive effect of isoptin-retard in a dose 240 mg/day, 17 males with mild and moderate hypertension receiving the drug underwent 24-h monitoring by SpaceLabs 5300 and pressure loading. A significant lowering of both mean systolic and diastolic pressure was found both in daytime and at night. A hypotensive effect persisted for 2 months. No case of serious cardiovascular complications, of noticeable shifts in blood biochemistry was reported.
为阐明缓释异搏定240毫克/天剂量的降压效果，17名轻度和中度高血压男性患者服用该药后，采用太空实验室5300进行了24小时监测及压力负荷测试。结果发现，白天和夜间的平均收缩压和舒张压均显著降低。降压效果持续了2个月。未报告严重心血管并发症及血液生化显著变化的病例。
