洪堡鼠李（鼠李科）植物中的毒素544和514对小鼠胎儿发育的影响。

Effect of toxins 544 and 514 from Karwinskia humboldtiana (buckthorn) plant upon fetal development of the mouse.

作者信息

Valadez-Alvizo R, Rodríguez-Alvarado A, Martínez de Villarreal L, González-Alanís R, Piñeyro-López A

机构信息

Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo Leoń, Monterrey, Mexico.

出版信息

Toxicon. 1993 Oct;31(10):1329-32. doi: 10.1016/0041-0101(93)90406-9.

DOI:10.1016/0041-0101(93)90406-9

PMID:8303727

Abstract

The teratogenic effect of toxins 544 and 514 from K. humboldtiana upon the mouse embryo was evaluated. One half of the LD50 dose for the mouse was administered at day 8 of gestation. At the end of pregnancy, reproduction and fetal data were recorded. Dams treated with toxin 544, but not with toxin 514, showed a higher incidence of reabsorptions, malformations, as well as lower fetal length compared to the control group.

摘要

评估了洪堡氏蟾蜍毒素544和514对小鼠胚胎的致畸作用。在妊娠第8天给予小鼠半数致死剂量（LD50）的毒素。在妊娠末期，记录生殖和胎儿数据。与对照组相比，用毒素544处理但未用毒素514处理的母鼠显示出更高的吸收、畸形发生率，以及胎儿长度更短。