Effect of toxins 544 and 514 from Karwinskia humboldtiana (buckthorn) plant upon fetal development of the mouse.

作者信息

Valadez-Alvizo R, Rodríguez-Alvarado A, Martínez de Villarreal L, González-Alanís R, Piñeyro-López A

机构信息

Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo Leoń, Monterrey, Mexico.

出版信息

Toxicon. 1993 Oct;31(10):1329-32. doi: 10.1016/0041-0101(93)90406-9.

DOI:10.1016/0041-0101(93)90406-9

PMID:8303727

Abstract

The teratogenic effect of toxins 544 and 514 from K. humboldtiana upon the mouse embryo was evaluated. One half of the LD50 dose for the mouse was administered at day 8 of gestation. At the end of pregnancy, reproduction and fetal data were recorded. Dams treated with toxin 544, but not with toxin 514, showed a higher incidence of reabsorptions, malformations, as well as lower fetal length compared to the control group.

摘要