Valadez-Alvizo R, Rodríguez-Alvarado A, Martínez de Villarreal L, González-Alanís R, Piñeyro-López A
Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad Autónoma de Nuevo Leoń, Monterrey, Mexico.
Toxicon. 1993 Oct;31(10):1329-32. doi: 10.1016/0041-0101(93)90406-9.
The teratogenic effect of toxins 544 and 514 from K. humboldtiana upon the mouse embryo was evaluated. One half of the LD50 dose for the mouse was administered at day 8 of gestation. At the end of pregnancy, reproduction and fetal data were recorded. Dams treated with toxin 544, but not with toxin 514, showed a higher incidence of reabsorptions, malformations, as well as lower fetal length compared to the control group.
评估了洪堡氏蟾蜍毒素544和514对小鼠胚胎的致畸作用。在妊娠第8天给予小鼠半数致死剂量（LD50）的毒素。在妊娠末期，记录生殖和胎儿数据。与对照组相比，用毒素544处理但未用毒素514处理的母鼠显示出更高的吸收、畸形发生率，以及胎儿长度更短。
